acquired purpura fulminans
Findings
No curated finding names acquired purpura fulminans yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A life-threatening, rapidly progressive thrombotic disorder affecting mainly neonates and children that is characterized by purpuric skin lesions and disseminated intravascular coagulation. PF may progress rapidly to multi-organ failure caused by thrombotic occlusion of small and medium-sized blood vessels. There are two forms of PF that are classified according to triggering mechanisms: acute infectious (the most common form), and idiopathic PF.
Definition from the Mondo Disease Ontology (MONDO:0018854), read 2026-09-29. CC BY 4.0.
Features
25 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal blistering of the skinHPOHP:0008066
- Frequent (30% to 79% of cases)
- Abnormal thrombosisHPOHP:0001977
- Frequent (30% to 79% of cases)
- AcrocyanosisHPOHP:0001063
- Frequent (30% to 79% of cases)
- Decreased erythrocyte sedimentation rateHPOHP:0025022
- Frequent (30% to 79% of cases)
- Disseminated intravascular coagulationHPOHP:0005521
- Frequent (30% to 79% of cases)
- Elevated circulating C-reactive protein concentrationHPOHP:0011227
- Frequent (30% to 79% of cases)
Show the remaining 13
- Prolonged partial thromboplastin timeHPOHP:0003645
- Frequent (30% to 79% of cases)
- Prolonged prothrombin timeHPOHP:0008151
- Frequent (30% to 79% of cases)
- Reduced protein C activityHPOHP:0005543
- Frequent (30% to 79% of cases)
- Reduced protein S activityHPOHP:0004855
- Frequent (30% to 79% of cases)
- ShockHPOHP:0031273
- Frequent (30% to 79% of cases)
- Skin rashHPOHP:0000988
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: acquired purpura fulminans
- Also called
- acquired PF