acquired hemophagocytic lymphohistiocytosis associated with malignant disease
MONDO:0015544Mondo
Findings
No curated finding names acquired hemophagocytic lymphohistiocytosis associated with malignant disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Features
39 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HemophagocytosisHPOHP:0012156
- Obligate (100% of cases)
- Abnormal circulating interleukin concentrationHPOHP:0011117
- Very frequent (80% to 99% of cases)
- Abnormal renal physiologyHPOHP:0012211
- Very frequent (80% to 99% of cases)
- Elevated circulating C-reactive protein concentrationHPOHP:0011227
- Very frequent (80% to 99% of cases)
- FeverHPOHP:0001945
- Very frequent (80% to 99% of cases)
- Immune dysregulationHPOHP:0002958
- Very frequent (80% to 99% of cases)
- Increased circulating ferritin concentrationHPOHP:0003281
- Very frequent (80% to 99% of cases)
- PancytopeniaHPOHP:0001876
- Very frequent (80% to 99% of cases)
- Reduced total natural killer cell countHPOHP:0040218
- Very frequent (80% to 99% of cases)
- SplenomegalyHPOHP:0001744
- Very frequent (80% to 99% of cases)
- AnemiaHPOHP:0001903
- Frequent (30% to 79% of cases)
- Decreased total neutrophil countHPOHP:0001875
- Frequent (30% to 79% of cases)
Show the remaining 27
- Elevated circulating hepatic transaminase concentrationHPOHP:0002910
- Frequent (30% to 79% of cases)
- Hematological neoplasmHPOHP:0004377
- Frequent (30% to 79% of cases)
- HyperbilirubinemiaHPOHP:0002904
- Frequent (30% to 79% of cases)
- HypertriglyceridemiaHPOHP:0002155
- Frequent (30% to 79% of cases)
- HypofibrinogenemiaHPOHP:0011900
- Frequent (30% to 79% of cases)
- Increased circulating lactate dehydrogenase concentrationHPOHP:0025435