acquired generalized lipodystrophy
Findings
No curated finding names acquired generalized lipodystrophy yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Acquired generalized lipodystrophy belongs to a group of lipodystrophic syndromes characterized by loss of adipose tissue, and is a syndrome of insulin resistance that leads to increased cardiovascular risk. Acquired generalized lipodystrophy is related to a selective loss of subcutaneous adipose tissue occurring exclusively at the extremities (face, legs, arms, palms and sometimes soles).
Definition from the Mondo Disease Ontology (MONDO:0019193), read 2026-09-29. CC BY 4.0.
Features
28 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Generalized lipodystrophyHPOHP:0009064
- Obligate (100% of cases)
- HyperinsulinemiaHPOHP:0000842
- Very frequent (80% to 99% of cases)
- Insulin resistanceHPOHP:0000855
- Very frequent (80% to 99% of cases)
- Abnormal cardiovascular system physiologyHPOHP:0011025
- Frequent (30% to 79% of cases)
- Abnormal circulating lipid concentrationHPOHP:0003119
- Frequent (30% to 79% of cases)
- AutoimmunityHPOHP:0002960
- Frequent (30% to 79% of cases)
- Calf muscle pseudohypertrophy
Show the remaining 16
- Acanthosis nigricansHPOHP:0000956
- Occasional (5% to 29% of cases)
- Accelerated skeletal maturationHPOHP:0005616
- Occasional (5% to 29% of cases)
- Acute pancreatitisHPOHP:0001735
- Occasional (5% to 29% of cases)
- CirrhosisHPOHP:0001394
- Occasional (5% to 29% of cases)
- Generalized hirsutismHPOHP:0002230
- Occasional (5% to 29% of cases)
- Generalized hyperpigmentationHPOHP:0007440
- Occasional (5% to 29% of cases)
Where it sits
Other names
3 names
Resolves to: acquired generalized lipodystrophy
- Also called
- acquired lipoatrophic diabetesLawrence syndromeLawrence-Seip syndrome