acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome
MONDO:0008696Mondo
Findings
No curated finding names acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
This syndrome is characterized by the association of acanthosis nigricans, insulin resistance, severe muscle cramps and acral hypertrophy.
Definition from the Mondo Disease Ontology (MONDO:0008696), read 2026-09-29. CC BY 4.0.
Features
9 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Acanthosis nigricansHPOHP:0000956
- Very frequent (80% to 99% of cases)
- Elevated circulating growth hormone concentrationHPOHP:0000845
- Very frequent (80% to 99% of cases)
- Enlarged polycystic ovariesHPOHP:0008675
- Very frequent (80% to 99% of cases)
- HirsutismHPOHP:0001007
- Very frequent (80% to 99% of cases)
- Insulin resistanceHPOHP:0000855
- Very frequent (80% to 99% of cases)
- Insulin-resistant diabetes mellitusHPOHP:0000831
- Very frequent (80% to 99% of cases)
- Muscle spasmHPOHP:0003394
- Very frequent (80% to 99% of cases)
- Polycystic ovariesHPOHP:0000147
- Very frequent (80% to 99% of cases)
- Enlarged kidneyHPOHP:0000105
- Frequent (30% to 79% of cases)