ABeta amyloidosis, dutch type
Findings
No curated finding names ABeta amyloidosis, dutch type yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D) is a form of HCHWA, a group of familial central nervous system disorders, characterized by severe cerebral amyloid angiopathy (CAA), hemorrhagic and non-hemorrhagic strokes and dementia.
Definition from the Mondo Disease Ontology (MONDO:0015033), read 2026-09-29. CC BY 4.0.
- Onset and course
- Death in early adulthood
HPO, annotations 2026-09-02
Features
9 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Atypical behaviorHPOHP:0000708
- Very frequent (80% to 99% of cases)
- Cerebral hemorrhageHPOHP:0001342
- Very frequent (80% to 99% of cases)
- DementiaHPOHP:0000726
- Very frequent (80% to 99% of cases)
- HeadacheHPOHP:0002315
- Very frequent (80% to 99% of cases)
- Mental deteriorationHPOHP:0001268
- Very frequent (80% to 99% of cases)
- StrokeHPOHP:0001297
- Very frequent (80% to 99% of cases)
- Cerebral amyloid angiopathy
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- APPHGNC:620
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
Other names
6 names
Resolves to: ABeta amyloidosis, dutch type
- Also called
- ABetaE22Q amyloidosiscerebral amyloid angiopathy, APP-related, Dutch variantHCHWA-DHCHWA, Dutch typehereditary cerebral haemorrhage with amyloidosis, Dutch typehereditary cerebral hemorrhage with amyloidosis, Dutch type