abdominal obesity-metabolic syndrome 3
Findings
No curated finding names abdominal obesity-metabolic syndrome 3 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any metabolic syndrome in which the cause of the disease is a mutation in the DYRK1B gene.
Definition from the Mondo Disease Ontology (MONDO:0014352), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Middle age onset · Young adult onset
HPO, annotations 2026-09-02
Features
11 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abdominal obesityHPOHP:0012743
- 26 of 26 reported patients
- HypertensionHPOHP:0000822
- 27 of 27 reported patients
- Type II diabetes mellitusHPOHP:0005978
- 25 of 27 reported patients
- Myocardial infarctionHPOHP:0001658
- 23 of 27 reported patients
- HypercholesterolemiaHPOHP:0003124
- 11 of 27 reported patients
- Elevated circulating LDL-C concentrationHPOHP:0003141
- 10 of 27 reported patients
- HyperglycemiaHPO
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- DYRK1BHGNC:3092
- Strong · Genomics England PanelApp · Autosomal dominant · 2021
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2021
- Moderate · Ambry Genetics · Autosomal dominant · 2022
- Moderate · PanelApp Australia · Autosomal dominant · 2025
Where it sits
- A kind of
Other names
3 names
Resolves to: abdominal obesity-metabolic syndrome 3
- Also called
- abdominal obesity-metabolic syndrome type 3DYRK1B metabolic syndromemetabolic syndrome caused by mutation in DYRK1B