AA amyloidosis
Findings
No curated finding names AA amyloidosis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Secondary amyloidosis is a form of amyloidosis, that complicates chronic inflammatory disorders (mainly rheumatoid arthritis) and is characterized by the aggregation and deposition of amyloid fibrils composed of serum amyloid A protein, an acute phase reactant. Although spleen, suprarenal gland, liver and gut are frequent sites of amyloid deposition, the clinical picture is dominated by renal involvement.
Definition from the Mondo Disease Ontology (MONDO:0019439), read 2026-09-29. CC BY 4.0.
Features
32 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Amyloid depositionHPOHP:0011034
- Very frequent (80% to 99% of cases)
- HypotensionHPOHP:0002615
- Very frequent (80% to 99% of cases)
- NephropathyHPOHP:0000112
- Very frequent (80% to 99% of cases)
- ProteinuriaHPOHP:0000093
- Very frequent (80% to 99% of cases)
- Renal amyloidosisHPOHP:0001917
- Very frequent (80% to 99% of cases)
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- Abnormal oral mucosa morphology
Show the remaining 20
- MalabsorptionHPOHP:0002024
- Frequent (30% to 79% of cases)
- MalnutritionHPOHP:0004395
- Frequent (30% to 79% of cases)
- NauseaHPOHP:0002018
- Frequent (30% to 79% of cases)
- Nephrotic syndromeHPOHP:0000100
- Frequent (30% to 79% of cases)
- Venous thrombosisHPOHP:0004936
- Frequent (30% to 79% of cases)
- VomitingHPOHP:0002013
- Frequent (30% to 79% of cases)
Where it sits
Other names
3 names
Resolves to: AA amyloidosis
- Also called
- inflammatory amyloidosisreactive amyloidosissecondary amyloidosis