Compound
thyroxine
The amino acid zwitterion formed from thyroxine by transfer of a proton from the carboxy group to the amino group. Major species at pH 7.3.
Definition from ChEBI (CHEBI:305790), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C15H11I4NO4
- Mass
- 776.872 g/mol
- Charge
- 0
- InChIKey
- XUIIKFGFIJCVMT-UHFFFAOYSA-N
- SMILES
- [NH3+]C(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Regulatory determinations
LiverTox likelihood score CLiverTox
LiverTox Likelihood Score C — probably linked to idiosyncratic liver injury, reported uncommonly. Chapter: "Thyroid Hormone". Source: LiverTox Master List (NBK571102).
The document·Public Domain (NLM/NIH)·Transcribed, not graded
Statements
1 statement
1 statement · 1 reference database · Subject: thyroxine · Sources: Rhea
- thyroxine is metabolised by SULT6B1ProteinRhea RHEA:26422Inferred only
Reactions
1 reaction
thyroxine+3'-phosphoadenylyl sulfatethyroxine sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT6B1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:26422CC BY 4.0Reference data
Other names
2 names
Resolves to: thyroxine
- Also called
- 2-Amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propionate
- Systematic name
- (2S)-2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate