efficacy (improvement) in tardive dyskinesia

no effect

A meta-analysis showed that baclofen, deanol and diazepam were no more effective than a placebo

PMID 10480663 · one of two readings recorded this

improvement of tardive dyskinesia, pooled Mantel-Haenszel odds ratio of deanol versus placebo; also pooled adverse events with deanol, abstract-level only

Not recorded as a finding: this platform holds no node for the endpoint

A meta-analysis showed that baclofen, deanol and diazepam were no more effective than a placebo.

PMID 10480663 · one of two readings recorded this

proportion of participants improved

unclear, n = 485

Meta-analysis of the impact of placebo (n=485) showed that 37.3% of participants showed an improvement

PMID 10480663 · one of two readings recorded this

risk of adverse events

increases

There was a significantly increased risk of adverse events associated with baclofen, deanol, L-dopa, oxypertine and reserpine

PMID 10480663 · one of two readings recorded this

dyskinetic movements

no effect

deanol acetamidobenzoate, administered in doses up to 1.5 g q.d. for three weeks to chronic schizophrenic patients presenting moderate to severe tardive dyskinesia, failed to alleviate the dyskinetic movements

PMID 117492 · one of two readings recorded this

schizophrenic symptoms

increases

there was a tendency for a significant increase in the schizophrenic symptoms of the deanol-treated group relative to the control group

PMID 117492 · one of two readings recorded this

amplitude of evoked potential components

increases

Several components of evoked potentials recorded from several scalp sites did show enhanced amplitude under drug treatment

PMID 120549 · one of two readings recorded this

benefit from warning signals in a complex reaction time task

increases

Contrary to earlier reports, elderly persons were found to be able to benefit from warning signals in a complex reaction time task

PMID 120549 · one of two readings recorded this

continuous serial decoding of digits

no effect

Tests of simple and complex reaction time and a test of continuous serial decoding of digits showed no enhancement with the drug

PMID 120549 · one of two readings recorded this

EEG spectrum

no effect

These changes were not accompanied by changes in the EEG spectrum as are seen with some other psychoactive drugs

PMID 120549 · one of two readings recorded this

learning a list of words

no effect

Deanol (900 mg/day for 21 days) had no effect on learning a list of words when tested at weekly intervals

PMID 120549 · one of two readings recorded this

learning of a word list at weekly tests, deanol 900 mg/day for 21 days in elderly humans

no effect

Not recorded as a finding: this platform holds no node for the endpoint

Deanol (900 mg/day for 21 days) had no effect on learning a list of words when tested at weekly intervals.

PMID 120549 · one of two readings recorded this

simple and complex reaction time

no effect

Tests of simple and complex reaction time and a test of continuous serial decoding of digits showed no enhancement with the drug

PMID 120549 · one of two readings recorded this

sensorial assessments and skin distension under suction

no effect

Large interindividual variations precluded any significant finding in the first study

PMID 12236885 · one of two readings recorded this

shear wave velocity

increases

The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness

PMID 12236885 · one of two readings recorded this

skin firmness

increases

The DMAE formulation under investigation increased skin firmness

PMID 12236885 · one of two readings recorded this

skin shear wave propagation velocity (skin firmness), topical 3% DMAE gel versus the same formulation without DMAE, split face

increases

Not recorded as a finding: this platform holds no node for the endpoint

The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness.

PMID 12236885 · one of two readings recorded this

skin shear wave propagation velocity, topical 3% 2-dimethylaminoethanol (DMAE) gel versus same formulation without DMAE, split-face, 30 volunteers

increases

Not recorded as a finding: this platform holds no node for the endpoint

The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness.

PMID 12236885 · one of two readings recorded this

improvement of tardive dyskinesia symptoms

no effect, p = 0.11

Cholinergic drugs showed a minor trend for improvement of tardive dyskinesia symptoms, but results were not statistically significant (RR 0.84, 95% confidence interval (CI) 0.68 to 1.04, p=0.11)

PMID 15610922 · one of two readings recorded this

bile flow and biliary secretion of cholesterol, phosphatidylcholine and bile salts after estradiol 17 beta-D-glucuronide cholestasis in rats pretreated with intravenous dimethylethanolamine (0.3 mg/kg/min for 15 h in sodium taurocholate) versus taurocholate-only controls; liver membrane fluidity by DPH fluorescence anisotropy

increases, bile flow and biliary cholesterol, phosphatidylcholine and bile salt secretion higher in DMAE-pretreated than in estradiol glucuronide controls during the cholestatic phase

Not recorded as a finding: this platform holds no node for the endpoint

Bile flow and the biliary secretion of cholesterol, phosphatidylcholine and bile salts were significantly higher in the dimethylethanolamine-pretreated rats than in estradiol 17 beta-D-glucuronide controls (p less than 0.02) during the cholestatic phase.

PMID 1646761 · one of two readings recorded this

bile flow and biliary secretion of cholesterol, phosphatidylcholine and bile salts during cholestatic phase

increases, p = 0.02

Bile flow and the biliary secretion of cholesterol, phosphatidylcholine and bile salts were significantly higher in the dimethylethanolamine-pretreated rats than in estradiol 17 beta-D-glucuronide controls (p less than 0.02) during the cholestatic phase

PMID 1646761 · one of two readings recorded this

bile flow, maximum inhibition

decreases

whereas in dimethylethanolamine-pretreated rats this decreased only from 3.2 +/- 0.4 (basal) to 2.3 +/- 0.4 microliters/min/100 gm

PMID 1646761 · one of two readings recorded this

bile flow, maximum inhibition

decreases

The maximum inhibition of bile flow was found 30 min after estradiol 17 beta-D-glucuronide administration, when it decreased from 3.5 +/- 0.4 microliters/min/100 gm (basal) to 0.9 +/- 0.3 microliters/min/100 gm in estradiol 17 beta-D-glucuronide controls

PMID 1646761 · one of two readings recorded this

membrane cholesterol enrichment and Na+,K(+)-ATPase inhibition

decreases, p = 0.05

the cholesterol enrichment and the inhibition of Na+,K(+)-ATPase (p less than 0.05) promoted by estradiol 17 beta-D-glucuronide administration in all membrane subfractions 30 and 180 min after administration

PMID 1646761 · one of two readings recorded this

membrane fluidity

decreases, p = 0.001

The inhibitory effect of estradiol 17 beta-D-glucuronide on bile flow was associated with a marked decrease of membrane fluidity (p less than 0.001)

PMID 1646761 · one of two readings recorded this

membrane fluidity

increases, p = 0.001

Dimethylethanolamine pretreatment significantly counteracted the reduction of membrane fluidity (p less than 0.001)

PMID 1646761 · one of two readings recorded this

polyunsaturated fatty acids in membrane phosphatidylcholine

increases

dimethylethanolamine-pretreated rats had more polyunsaturated fatty acids in membrane phosphatidylcholine with respect to the control groups

PMID 1646761 · one of two readings recorded this

sinusoidal Na+,K(+)-ATPase activity

decreases, p = 0.05

with a cholesterol enrichment of microsomes, sinusoidal and canalicular liver plasma membranes and inhibition of sinusoidal Na+,K(+)-ATPase activity (p less than 0.05)

PMID 1646761 · one of two readings recorded this

choice reaction time

unclear

DMAE p-Glu produced a significant positive effect on scores in the Buschke test, as well as a slight but significant difference on choice reaction time

PMID 19756528 · one of two readings recorded this

Buschke test score

increases

DMAE p-Glu produced a significant positive effect on scores in the Buschke test, as well as a slight but significant difference on choice reaction time

PMID 19756528 · one of two readings recorded this

extracellular acetylcholine

increases

DMAE p-Glu increased the extracellular levels of choline and acetylcholine in the medial prefrontal cortex, as assessed by intracerebral microdialysis

PMID 19756528 · one of two readings recorded this

extracellular choline

increases

DMAE p-Glu increased the extracellular levels of choline and acetylcholine in the medial prefrontal cortex, as assessed by intracerebral microdialysis

PMID 19756528 · one of two readings recorded this

long-term memory score on the Buschke test in healthy young men given scopolamine intravenously, DMAE p-Glu versus control

increases

Not recorded as a finding: this platform holds no node for the endpoint

Clinical study results show that scopolamine induced a memory deficit and that DMAE p-Glu produced a significant positive effect on scores in the Buschke test, as well as a slight but significant difference on choice reaction time.

PMID 19756528 · one of two readings recorded this

scopolamine-induced deficit in passive avoidance

decreases

reduced scopolamine-induced memory deficit in passive avoidance behavior

PMID 19756528 · one of two readings recorded this

spatial memory performance

increases

improved performance in a test of spatial memory

PMID 19756528 · one of two readings recorded this

blood flow in the stomach wall

increases

This effect is accompanied by activation of the peristalsis of bowels and by an increase in the blood flow in the wall of stomach

PMID 22702105 · one of two readings recorded this

peristalsis of bowels

increases

This effect is accompanied by activation of the peristalsis of bowels and by an increase in the blood flow in the wall of stomach

PMID 22702105 · one of two readings recorded this

stress-induced erosive ulcerous damage of the gastric mucosa

decreases

stress-induced erosive ulcerous damage of the mucous membrane of stomach showed evidence of the preventive activity of deanol aceglumate

PMID 22702105 · one of two readings recorded this

collagen fiber density

increases

In addition, 0.2% DMAE alone also significantly increased epidermal thickness and density of collagen fiber when compared to aging control

PMID 25133239 · one of two readings recorded this

collagen fiber density

increases

When treated with 0.1% DMAE + AA or 0.2% DMAE + AA, both epidermal and dermal thickness and density of collagen fiber were significantly elevated over those of aging control group

PMID 25133239 · one of two readings recorded this

collagen fiber density

increases

When treated with 0.1% DMAE + AA or 0.2% DMAE + AA, both epidermal and dermal thickness and density of collagen fiber were significantly elevated over those of aging control group

PMID 25133239 · one of two readings recorded this

collagen type I mRNA expression

increases

Collagen type I expression was greatly upregulated in response to both 0.1% DMAE + AA and 0.2% DMAE + AA treatments, which showed no significant difference to that of sham control

PMID 25133239 · one of two readings recorded this

collagen type I mRNA expression

increases

Collagen type I expression was greatly upregulated in response to both 0.1% DMAE + AA and 0.2% DMAE + AA treatments, which showed no significant difference to that of sham control

PMID 25133239 · one of two readings recorded this

collagen type III mRNA expression

increases

When treated with 0.1% DMAE + AA, 0.2% DMAE + AA, or 0.2% DMAE alone, transcript levels for collagen type III were considerably elevated over aging control group

PMID 25133239 · one of two readings recorded this

collagen type III mRNA expression

increases

When treated with 0.1% DMAE + AA, 0.2% DMAE + AA, or 0.2% DMAE alone, transcript levels for collagen type III were considerably elevated over aging control group

PMID 25133239 · one of two readings recorded this

collagen type III mRNA expression

increases

When treated with 0.1% DMAE + AA, 0.2% DMAE + AA, or 0.2% DMAE alone, transcript levels for collagen type III were considerably elevated over aging control group

PMID 25133239 · one of two readings recorded this

dermal thickness

increases

When treated with 0.1% DMAE + AA or 0.2% DMAE + AA, both epidermal and dermal thickness and density of collagen fiber were significantly elevated over those of aging control group

PMID 25133239 · one of two readings recorded this

dermal thickness

increases

When treated with 0.1% DMAE + AA or 0.2% DMAE + AA, both epidermal and dermal thickness and density of collagen fiber were significantly elevated over those of aging control group

PMID 25133239 · one of two readings recorded this

epidermal and dermal thickness and collagen fibre density by H&E and Masson trichrome histology; skin water content; skin hydroxyproline content; collagen I/III, MMP-1 and TIMP-1 mRNA by qRT-PCR, in D-galactose-aged rat skin after intradermal DMAE microinjection

increases

Not recorded as a finding: this platform holds no node for the endpoint

In addition, 0.2% DMAE alone also significantly increased epidermal thickness and density of collagen fiber when compared to aging control.

PMID 25133239 · one of two readings recorded this

epidermal thickness and dermal collagen fibre density by H&E and Masson trichrome histology image analysis; skin water content by wet/dry weight; skin hydroxyproline by assay kit; collagen I, collagen III, MMP-1 and TIMP-1 mRNA by qRT-PCR, in D-galactose aged rat skin after intradermal DMAE (0.2% DMAE alone arm)

increases, 0.2% DMAE alone significantly increased epidermal thickness and collagen fibre density versus aging control (no numeric estimate stated)

Not recorded as a finding: this platform holds no node for the endpoint

In addition, 0.2% DMAE alone also significantly increased epidermal thickness and density of collagen fiber when compared to aging control.

PMID 25133239 · one of two readings recorded this

epidermal thickness

increases

In addition, 0.2% DMAE alone also significantly increased epidermal thickness and density of collagen fiber when compared to aging control

PMID 25133239 · one of two readings recorded this

epidermal thickness

increases

When treated with 0.1% DMAE + AA or 0.2% DMAE + AA, both epidermal and dermal thickness and density of collagen fiber were significantly elevated over those of aging control group

PMID 25133239 · one of two readings recorded this

epidermal thickness

increases

When treated with 0.1% DMAE + AA or 0.2% DMAE + AA, both epidermal and dermal thickness and density of collagen fiber were significantly elevated over those of aging control group

PMID 25133239 · one of two readings recorded this

hydroxyproline content

increases

Hydroxyproline content were greatly increased in aging skin treated with both 0.1% DMAE + AA and 0.2% DMAE + AA complex, which showed significant differences when compared to all other aging groups

PMID 25133239 · one of two readings recorded this

hydroxyproline content

increases

Hydroxyproline content were greatly increased in aging skin treated with both 0.1% DMAE + AA and 0.2% DMAE + AA complex, which showed significant differences when compared to all other aging groups

PMID 25133239 · one of two readings recorded this

MMP-1 mRNA expression

increases

MMP-1 messages increased in response to either 0.1% DMAE + AA or 0.2% DMAE + AA treatment, which showed a statistically significant difference from that of aging control, but not sham control rats

PMID 25133239 · one of two readings recorded this

MMP-1 mRNA expression

increases

MMP-1 messages increased in response to either 0.1% DMAE + AA or 0.2% DMAE + AA treatment, which showed a statistically significant difference from that of aging control, but not sham control rats

PMID 25133239 · one of two readings recorded this

skin water content

no effect

There were no statistically significant differences in water content among all groups

PMID 25133239 · one of two readings recorded this

TIMP-1 mRNA expression

decreases

In contrast, transcript levels for TIMP-1 in all aging groups were significantly downregulated to a much lower level of that of sham control

PMID 25133239 · one of two readings recorded this

asthenic and cognitive disorders by psychopathological and psychometric examination (instruments not named in the abstract), nooclerin (deanoli aceglumas) add-on versus psychopharmacotherapy alone

decreases

Not recorded as a finding: this platform holds no node for the endpoint

There was a significant reduction of asthenic and cognitive disorders in the main group compared to the controls.

PMID 29053118 · one of two readings recorded this

asthenic and cognitive disorders, psychopathological and psychometric examination (scales not named), nooclerin (deanol aceglumate) 1000 mg/day add-on for 30 days versus controls on psychopharmacological treatment alone

decreases

Not recorded as a finding: the paper never states the instrument the node requires

There was a significant reduction of asthenic and cognitive disorders in the main group compared to the controls.

PMID 29053118 · one of two readings recorded this

asthenic disorders

decreases

There was a significant reduction of asthenic and cognitive disorders in the main group compared to the controls

PMID 29053118 · one of two readings recorded this

cognitive disorders

decreases

There was a significant reduction of asthenic and cognitive disorders in the main group compared to the controls

PMID 29053118 · one of two readings recorded this

adverse events

unclear, n = 106

adverse events (RR 0.56, 95% CI 0.15 to 2.14; 106 people, 4 RCTs)

PMID 29553158 · one of two readings recorded this

deterioration of TD symptoms

no effect, n = 147

Eight trials found that cholinergic drugs may make little or no difference to deterioration of TD symptoms (low-quality evidence, RR 1.11, 95% CI 0.55 to 2.24; 147 people)

PMID 29553158 · one of two readings recorded this

leaving the study early

unclear, n = 288

leaving the study early (RR 1.09,95% CI 0.56 to 2.10; 288 people 12 RCTs)

PMID 29553158 · one of two readings recorded this

mental state

unclear, n = 77

effects on mental state (RR 0.50, 95% CI 0.10 to 2.61; 77 people, 5 RCTs)

PMID 29553158 · one of two readings recorded this

no clinically important improvement in TD symptoms

unclear, n = 27

We are uncertain about the effect of new or old cholinergic drugs on no clinically important improvement in TD symptoms when compared with placebo; the quality of evidence was very low (RR 0.89, 95% CI 0.65 to 1.23; 27 people, 4 RCTs)

PMID 29553158 · one of two readings recorded this

alcohol withdrawal symptoms

decreases

Nooclerin reduced alcohol withdrawal symptoms more significantly throughout the whole study period

PMID 29658504 · one of two readings recorded this

Clinical Institute Withdrawal Assessment of Alcohol Scale (CIWA-Ar)

decreases

There were significant between-group differences on the Clinical Institute Withdrawal Assessment of Alcohol Scale (CIWA-Ar) and the Multidimensional Fatigue Inventory (МFI-20)

PMID 29658504 · one of two readings recorded this

Multidimensional Fatigue Inventory (MFI-20)

unclear

There were significant between-group differences on the Clinical Institute Withdrawal Assessment of Alcohol Scale (CIWA-Ar) and the Multidimensional Fatigue Inventory (МFI-20)

PMID 29658504 · one of two readings recorded this

SDSC scores

no effect

No significant positive changes were detected in the placebo group

PMID 31851171 · one of two readings recorded this

SDSC subscale: disorders of excessive somnolence

decreases, p = 0.001

a significant decrease in the scores on scales 'Disorders of initiating and maintaining sleep', 'Disorders of excessive somnolence' (p<0.001)

PMID 31851171 · one of two readings recorded this

SDSC subscale: disorders of initiating and maintaining sleep

decreases, p = 0.001

a significant decrease in the scores on scales 'Disorders of initiating and maintaining sleep', 'Disorders of excessive somnolence' (p<0.001)

PMID 31851171 · one of two readings recorded this

SDSC subscale: sleep wake transition disorders

decreases, p = 0.01

'Sleep wake transition disorders' (p<0.01)

PMID 31851171 · one of two readings recorded this

total score on the Sleep Disturbance Scale for Children (SDSC)

decreases, p = 0.001

reduced total score on SDSC (p<0.001)

PMID 31851171 · one of two readings recorded this

age of onset and type of specific neoplasms

no effect

Also, there was no statistically significant difference between control and treated animals in the age of onset or the type of specific neoplasms

PMID 3361965 · one of two readings recorded this

age-related organ structure or morphology

no effect

No changes in age-related organ structure or morphology were observed with dimethylaminoethanol treatment, except for an apparent decrease in the amount of lipofuscin in the liver judged in histological sections

PMID 3361965 · one of two readings recorded this

average survival

no effect

Administration in the drinking water of 10 mM dimethylaminoethanol to the C3H/HeN mice or 15 mM to the C3H/HeJ(+) mice did not result in significant differences between treated and untreated groups in average survival

PMID 3361965 · one of two readings recorded this

incidence of cryptogenic neoplasms (all sites combined), C3H/HeJ(+) mice

Not recorded as a finding: all-site-cancer-incidence node exists, but the sentence gives percentages (89% untreated vs 88% treated) with no stated test or two-sided statement of no difference in that sentence; the separate no-difference sentence concerns age of onset and neoplasm type, not incidence

Among untreated C3H/HeJ(+) females, 89% developed neoplasms of the mammary gland, ovary, liver, lung and reticuloendothelial system, while the incidence was 88% in the treated mice.

PMID 3361965 · one of two readings recorded this

lipofuscin in the liver

decreases

No changes in age-related organ structure or morphology were observed with dimethylaminoethanol treatment, except for an apparent decrease in the amount of lipofuscin in the liver judged in histological sections

PMID 3361965 · one of two readings recorded this

neoplasm incidence

no effect

In C3H/HeN females, neoplasms of the mammary gland, ovary, liver, lung and lymphatic system occurred in 57% and in 60% of treated mice

PMID 3361965 · one of two readings recorded this

neoplasm incidence

no effect

Among untreated C3H/HeJ(+) females, 89% developed neoplasms of the mammary gland, ovary, liver, lung and reticuloendothelial system, while the incidence was 88% in the treated mice

PMID 3361965 · one of two readings recorded this

neoplasm induction by dimethylaminoethanol

no effect

Dimethylaminoethanol did not induce any neoplasms

PMID 3361965 · one of two readings recorded this

tardive dyskinesia by subjective clinical impression and scoring of filmed sequences, deanol acetamidobenzoate 2.0 g/day for four weeks versus placebo, crossover

no effect, n = 14

Not recorded as a finding: this platform holds no node for the endpoint

Patients' conditions improved significantly from baseline scores while receiving both deanol and placebo, but there was no distinction between the two treatments.

PMID 347112 · one of two readings recorded this

tardive dyskinesia condition versus baseline scores

unclear

Patients' conditions improved significantly from baseline scores while receiving both deanol and placebo, but there was no distinction between the two treatments

PMID 347112 · one of two readings recorded this

tardive dyskinesia condition versus baseline scores

unclear

Patients' conditions improved significantly from baseline scores while receiving both deanol and placebo, but there was no distinction between the two treatments

PMID 347112 · one of two readings recorded this

tardive dyskinesia response, deanol versus placebo

no effect

Patients' conditions improved significantly from baseline scores while receiving both deanol and placebo, but there was no distinction between the two treatments

PMID 347112 · one of two readings recorded this

tardive dyskinesia severity by subjective clinical impression and scoring of filmed sequences, deanol acetamidobenzoate 2.0 g/day for four weeks versus placebo, crossover

no effect, n = 14

Not recorded as a finding: this platform holds no node for the endpoint

Patients' conditions improved significantly from baseline scores while receiving both deanol and placebo, but there was no distinction between the two treatments.

PMID 347112 · one of two readings recorded this

dopamine release from striatum slices after postnatal hypoxia in adult animals

decreases

Perinatal DMAE- but not PIR-treatment diminishes the consequences of postnatal oxygen deprivation regarding the motor activity as well as the dopamine release of adult animals

PMID 3778435 · one of two readings recorded this

explorative activity (own effect of DMAE)

decreases

Only minor effects were seen after DMAE-treatment, but a marked depressant own effect on the explorative activity was detectable

PMID 3778435 · one of two readings recorded this

motor activity after postnatal hypoxia in adult animals

decreases

Perinatal DMAE- but not PIR-treatment diminishes the consequences of postnatal oxygen deprivation regarding the motor activity as well as the dopamine release of adult animals

PMID 3778435 · one of two readings recorded this

open field hyperactivity of developing rats

unclear

Only minor effects were seen after DMAE-treatment, but a marked depressant own effect on the explorative activity was detectable

PMID 3778435 · one of two readings recorded this

open field hyperactivity of developing rats

decreases

Hypoxia-caused open field hyperactivity of developing rats was found to be reduced to control values in PIR-treated rats

PMID 3778435 · one of two readings recorded this

improvement in tardive dyskinesia symptoms during first treatment phase

unclear

Improvement occurred in all patients during the first treatment phase regardless of which drug the patients received; seven patients were on deanol and three on placebo during this time

PMID 406628 · one of two readings recorded this

hepatic glutathione (GSH) depletion after paracetamol

no effect, paracetamol-induced depletion not influenced by DMAE in rats and mice

Not recorded as a finding: reduced-glutathione node is bound to erythrocyte, whole-blood or plasma GSH; this is hepatic tissue GSH

Paracetamol-induced depletion of hepatic glutathione (GSH) was not influenced by the simultaneous administration of DMAE in rats and mice.

PMID 582737 · one of two readings recorded this

hepatoprotective effect of DMAE across doses

decreases

This hepatoprotective effect of DMAE depended on the applied dose in rats, but there was no complete protection following the highest dose

PMID 582737 · one of two readings recorded this

p-hydroxylation of aniline in 9000Xg supernatant of liver homogenate

decreases

Diminished p-hydroxylation of aniline in a 9000Xg supernatant of rat and mouse liver homogenates in the presence of DMAE indicated an inhibition of microsomal mixed-function oxidase activity

PMID 582737 · one of two readings recorded this

paracetamol-induced depletion of hepatic glutathione (GSH), rats and mice

no effect

Not recorded as a finding: reduced-glutathione node is blood, erythrocyte or plasma GSH by enzymatic recycling or chromatography; this is hepatic tissue GSH, a different matrix

Paracetamol-induced depletion of hepatic glutathione (GSH) was not influenced by the simultaneous administration of DMAE in rats and mice.

PMID 582737 · one of two readings recorded this

paracetamol-induced depletion of hepatic glutathione (GSH)

no effect

Paracetamol-induced depletion of hepatic glutathione (GSH) was not influenced by the simultaneous administration of DMAE in rats and mice

PMID 582737 · one of two readings recorded this

paracetamol-induced increase in serum enzyme activities (GOT, GPT, SDH)

decreases

2-Dimethylaminoethanol (DMAE; 0.1--0.5 g/kg) significantly reduced the paracetamol-induced increments of serum-enzyme activities (GOT, GPT, SDH) in rats and mice

PMID 582737 · one of two readings recorded this

paracetamol-induced increase in serum enzyme activities (GOT, GPT, SDH)

decreases

2-Dimethylaminoethanol (DMAE; 0.1--0.5 g/kg) significantly reduced the paracetamol-induced increments of serum-enzyme activities (GOT, GPT, SDH) in rats and mice

PMID 582737 · one of two readings recorded this

serum sorbitol dehydrogenase (SDH) activity after paracetamol

decreases, significantly reduced paracetamol-induced increments (no number stated)

Not recorded as a finding: no outcome node for serum SDH activity

2-Dimethylaminoethanol (DMAE; 0.1--0.5 g/kg) significantly reduced the paracetamol-induced increments of serum-enzyme activities (GOT, GPT, SDH) in rats and mice.

PMID 582737 · both readings recorded this

urinary elimination of free paracetamol and paracetamol glucuronide

increases

Metabolic disposition of paracetamol in the urine of rats showed an enhanced elimination of free paracetamol and the glucuronide in the DMAE-treated group

PMID 582737 · one of two readings recorded this

urinary paracetamol mercapturate excretion

no effect

whereas the mercapturate excretion remained unchanged

PMID 582737 · one of two readings recorded this

mean rating of oral tardive dyskinesia movements after 30 days, deanol 1 g and 2 g per day versus placebo (rating instrument not named)

decreases, n = 11

Not recorded as a finding: this platform holds no node for the endpoint

Statistical analysis showed that after 30 days treatment, there was a significant reduction in the mean rating of the movements of the group of 11 subjects on 2 g deanol per day.

PMID 6942835 · one of two readings recorded this

mean rating of oral tardive dyskinesia movements, deanol 1 g or 2 g per day versus placebo for 30 days

decreases, n = 11

Not recorded as a finding: this platform holds no node for the endpoint

Statistical analysis showed that after 30 days treatment, there was a significant reduction in the mean rating of the movements of the group of 11 subjects on 2 g deanol per day.

PMID 6942835 · one of two readings recorded this

mean rating of oral tardive dyskinesia movements

decreases, n = 11

after 30 days treatment, there was a significant reduction in the mean rating of the movements of the group of 11 subjects on 2 g deanol per day

PMID 6942835 · one of two readings recorded this

substantial reduction in movement (responders)

decreases

Six of these subjects showed substantial reduction in movement

PMID 6942835 · one of two readings recorded this

behavioral reactivity (visual and tactile stimuli, resistance to capture and handling, vocalization, muscular tension, non-contingent aversive stimulation)

no effect

deanol had no significant effect on the behaviors

PMID 7312898 · one of two readings recorded this

behavioral reactivity (visual and tactile stimuli, resistance to capture and handling, vocalization, muscular tension, non-contingent aversive stimulation)

increases

animals receiving HC-3 only clearly showed responses which were enhanced above the levels of any of the other treatment groups

PMID 7312898 · one of two readings recorded this

HC-3 enhanced behavior

decreases

deanol had a dose-dependent effect of suppressing HC-3 enhanced behavior

PMID 7312898 · one of two readings recorded this

shock-induced defence reaction

no effect

With the exception of the defence reaction, all behaviors showed significant effects between the various drug treatments

PMID 7312898 · one of two readings recorded this

activity response to light-flash, age effect (aged versus young-adult quail)

modulates

Aged quail differed from young-adults in changes in motor activity in response to light flashes

PMID 830732 · one of two readings recorded this

basal heart rate

no effect

There were no detectable differences in latency to mount or in basal heart rate, either as a function of age or as a function of DMAE treatment

PMID 830732 · one of two readings recorded this

body weight and daily fluid intake

no effect

No significant differences between the groups were observed in body weight or daily fluid intake

PMID 830732 · one of two readings recorded this

body weight, group comparison (stated without instrument or conditions)

no effect

Not recorded as a finding: agentless passive sentence that does not name the compound; body-mass node requires stated weighing conditions the abstract does not give

No significant differences between the groups were observed in body weight or daily fluid intake.

PMID 830732 · one of two readings recorded this

latency to mount a female quail and basal heart rate at 243-249 weeks of age

no effect

Not recorded as a finding: no outcome node for sexual mounting latency or basal heart rate; agentless passive

There were no detectable differences in latency to mount or in basal heart rate, either as a function of age or as a function of DMAE treatment.

PMID 830732 · one of two readings recorded this

latency to mount (sexual mounting response to a female quail)

no effect

There were no detectable differences in latency to mount or in basal heart rate, either as a function of age or as a function of DMAE treatment

PMID 830732 · one of two readings recorded this

life-span after start of treatment

decreases

the DMAE-treated group has a shorter life-span after start of treatment (49 weeks) than the controls (69 weeks)

PMID 830732 · one of two readings recorded this

functional state of central nervous system

modulates

The obtained results allowed to conclude, that high (2.76 mg/m3) concentration of dimethylethanolamine influenced on functional state of central nervous system

PMID 9221114 · one of two readings recorded this

myorelaxant action

no effect

In the same time the sufficient grounds for the attribution of dimethylethanolamine to myorelaxants were absent, since in our experiments we used only very high concentrations of this agent

PMID 9221114 · one of two readings recorded this

summarizing liminal index (SLI)

unclear

SLI changes pointed to disturbance of dynamic equilibrium between processes of inhibition and excitation with prevalence of latter

PMID 9221114 · one of two readings recorded this