Skip to content Catalyst Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.
The graph Reference layer How it works Build on it A reference for what the literature reports. Not medical advice.
© 2026 Catalyst Privacy Terms Reference data under the licences listed on the attribution page .
↑ Top
choline / Record
Papers screened
Screened 607
Admitted 3
Discarded 95
Not read 509 16 queries
"choline"[ti] [rct] "choline"[ti] [systematic_review] "choline"[ti] [meta_analysis] clinicaltrials.gov intr search: query.intr=choline "choline"[ti] [observational] cited by PMID:19630440 [cited]; about CHEBI:15354 by its own indexing cited by PMID:22981426 [cited]; about CHEBI:15354 by its own indexing cited by PMID:22981426 [observational]; about CHEBI:15354 by its own indexing cited by PMID:22981426 [rct]; about CHEBI:15354 by its own indexing cited by PMID:26762282 [cited]; about CHEBI:15354 by its own indexing cited by PMID:26678028 [cited]; about CHEBI:15354 by its own indexing cited by PMID:27147264 [cited]; about CHEBI:15354 by its own indexing pipeline:batch cited by PMID:25044037 [cited]; about CHEBI:15354 by its own indexing cited by PMID:25044037 [observational]; about CHEBI:15354 by its own indexing cited by PMID:26754058 [cited]; about CHEBI:15354 by its own indexing Produced a finding 3 papers Discarded — the wrong intervention 52 papers NCT00158249 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29 Back to choline
NCT00223236 intervention×1 — no declared intervention names choline
clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00355368 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00377299 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00462644 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00474253 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00509067 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00545662 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00616772 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00619723 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00639158 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00727246 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00751179 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT00950352 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT01149538 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT01441960 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT01749982 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT01907217 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT01941628 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT02074735 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT02144675 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT02369536 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT02425449 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT02582905 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT02635542 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT02735473 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT03039023 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT03403205 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT03440814 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT03726671 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT03758118 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT03809611 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT04526197 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT04526210 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT04560816 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT04581395 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT04610580 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT04774237 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT04886960 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT05270863 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT05303324 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT05319899 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29
NCT05319912 intervention×1 — no declared intervention names choline clinicaltrials.gov intr search: query.intr=choline 2026-09-29 PMID:30024551 no claim extracted — reagent_not_exposure pipeline:batch 2026-10-05 PMID:30192819 no claim extracted — reagent_not_exposure pipeline:batch 2026-10-05 PMID:40913113 no claim extracted — subject_is_the_outcome pipeline:batch 2026-10-05 PMID:41146117 no claim extracted — subject_is_the_outcome pipeline:batch 2026-10-05 PMID:42108701 no claim extracted — subject_is_the_outcome pipeline:batch 2026-10-05 PMID:23631562 no claim extracted — subject_is_the_outcome pipeline:batch 2026-10-11 PMID:41491031 no claim extracted — reagent_not_exposure pipeline:batch 2026-10-12 PMID:38718704 no claim extracted — reagent_not_exposure pipeline:batch 2026-10-12 PMID:38900416 no claim extracted — reagent_not_exposure pipeline:batch 2026-10-12 Discarded — another reason, stated per paper 27 papers NCT02260817 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT00381381 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT00520546 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT00673881 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT00928252 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT00986583 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT01009931 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT01395030 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT01502813 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT02197104 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT02397408 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT02849171 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT02914119 design×1 — studyType OBSERVATIONAL -- only INTERVENTIONAL is extracted clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT03404648 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT04422431 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=choline 2026-09-29 PMID:27390868 no claim extracted — subject_absent — DOSED: Choline acetyltransferase (ChAT) gene SNPs as genetic risk factors for Alzheimer's disease; choline itself is neither given nor measured | Choline acetyltransferase (ChAT) gene polymorphisms and Alzheimer's disease risk; no choline exposure or measurement pipeline:batch 2026-10-05 PMID:36161993 no claim extracted — design_has_no_evidence_type pipeline:batch 2026-10-05 PMID:41496893 no claim extracted — cause not determined pipeline:batch 2026-10-05 PMID:1120141 no claim extracted — cause not determined — DOSED: rat liver microsomes with endogenous diacylglycerols and phosphatidylcholines, incubated with CDP-choline / CDP-ethanolamine / CMP (abstract) pipeline:batch 2026-10-11 PMID:2542702 no claim extracted — subject_absent — DOSED: acetyl-L-carnitine, 50 mg/kg per day, subchronic, rats (abstract) | acetyl-L-carnitine, 50 mg/kg per day, abstract pipeline:batch 2026-10-11 PMID:15846601 no claim extracted — subject_absent — DOSED: CDP-choline (cytidine 5'-diphosphocholine, citicoline), abstract | CDP-choline (cytidine 5'-diphosphocholine, citicoline), a distinct compound from choline; abstract pipeline:batch 2026-10-12 PMID:41417236 no claim extracted — cause not determined pipeline:batch 2026-10-12 PMID:41482637 no claim extracted — subject_absent — DOSED: diazoxide choline extended-release (DCCR) tablets, abstract | diazoxide choline extended-release (DCCR) tablets, a diazoxide salt, not choline; abstract pipeline:batch 2026-10-12 PMID:42374230 no claim extracted — cause not determined (one pass only) — measured: membership of NIHSS trajectory groups (moderate, persistent-severe) from a group-based trajectory model, not a single NIHSS total score pipeline:batch 2026-10-12 PMID:36639249 no claim extracted — subject_absent — DOSED: Diazoxide choline extended-release tablet (DCCR), abstract; a distinct named drug salt, choline is only its counter-ion, not the dosed exposure | diazoxide choline extended-release tablet (DCCR), abstract pipeline:batch 2026-10-12 PMID:36927273 no claim extracted — subject_absent — DOSED: CDP-choline (cytidine 5'-diphosphocholine) 500 mg plus galantamine 16 mg, Methods; a distinct named compound given in combination, versus cellulose placebo | CDP-choline (cytidine 5'-diphosphocholine) 500 mg combined with galantamine 16 mg versus placebo, abstract pipeline:batch 2026-10-12 PMID:39300341 no claim extracted — subject_absent — DOSED: Choline alphoscerate (alpha-glyceryl phosphorylcholine, alphaGPC), SHCog soft capsule 600 mg, abstract; a distinct named compound, not choline itself | choline alphoscerate (alpha glyceryl phosphorylcholine, alphaGPC), SHCog soft capsule 600 mg, abstract pipeline:batch 2026-10-12 Discarded — no extractable result 7 papers NCT00720343 declared_contrast×2 — no posted analysis compares a choline arm with a placebo/no-intervention arm and carries a p-value (Choline=EXPERIMENTAL+subject, Placebo=PLACEBO_COMPARATOR) clinicaltrials.gov intr search: query.intr=choline 2026-09-29 NCT04764162 declared_contrast×2 — no posted analysis compares a choline arm with a placebo/no-intervention arm and carries a p-value (Choline=unmatched, Placebo=unmatched) clinicaltrials.gov intr search: query.intr=choline 2026-09-29 PMID:27759060 no claim extracted — direction_not_in_words pipeline:batch 2026-10-12 PMID:41683281 claims extracted but refused by the deterministic validators pipeline:batch 2026-10-12 PMID:42797005 claims extracted but the two passes did not agree pipeline:batch 2026-10-12 PMID:37340479 claims extracted but the two passes did not agree pipeline:batch 2026-10-12 PMID:38004152 no claim extracted — no_quantitative_result pipeline:batch 2026-10-12 Discarded — no comparator 5 papers PMID:36460779 no claim extracted — comparator_not_absence pipeline:batch 2026-10-12 PMID:36840817 no claim extracted — comparator_not_absence pipeline:batch 2026-10-12 PMID:37764658 no claim extracted — comparator_not_absence pipeline:batch 2026-10-12 PMID:41524941 no claim extracted — comparator_not_absence pipeline:batch 2026-10-12 PMID:41687879 no claim extracted — comparator_not_absence pipeline:batch 2026-10-12 Discarded — an endpoint this vocabulary does not hold 4 papers PMID:36041182 no claim extracted — no_outcome_node — measured: neural tube defect occurrence in offspring, pooled odds ratio low vs high maternal choline intake or serum total choline in case-control studies | neural tube defect occurrence in offspring (anencephaly, spina bifida), pooled Mantel-Haenszel OR from case-control studies pipeline:batch 2026-10-05 PMID:42380861 no claim extracted — no_outcome_node — measured: incident all-cause dementia, Langa-Weir classification from cognitive scores/proxy interview, hazard ratio by dietary intake quintile | incident all-cause dementia, Langa-Weir algorithm in HRS cohort / pooled prospective cohorts pipeline:batch 2026-10-05 PMID:638162 no claim extracted — no_outcome_node — measured: lymphatic output of triglyceride and phospholipid, thoracic duct lymph fistula rat | lymphatic output of triglyceride and phospholipid (thoracic duct lymph fistula, rat) pipeline:batch 2026-10-11 PMID:39956364 no claim extracted — no_outcome_node — measured: elicited imitation memory task, short-delay adjacent pairs (sequential memory) | elicited imitation (EI) memory task, short-delay adjacent-pairs sequential memory score pipeline:batch 2026-10-12