biphenyl

reference values for blood PCB concentration

1.2-8.28 microg/L (males); 2.69-5.17 microg/L (females); overall range 0.9-56 microg/L

The PCBs RVs resulted between 1.2 e 8.28 microg/L for males and between 2.69 e 5.17 microg/L for females the general range varied from 0.9 to 56 microg/L.

PMID:15134393 · one of two readings recorded this

carcinogenicity and noncancer health hazards of oral biphenyl exposure (male rat urinary bladder tumors, female mouse liver tumors, kidney toxicity), narrative synthesis of experimental animal bioassays and mechanistic studies for EPA IRIS

increases

Not recorded as a finding: a review that discusses its trials without pooling them

The available health effects data for biphenyl provides suggestive evidence for carcinogenicity in humans, based on increased incidences of male rat urinary bladder tumors at high exposure levels and on female mouse liver tumors.

PMID:26529796 · one of two readings recorded this

Carcinogenicity (male rat urinary bladder tumors, female mouse liver tumors) and kidney toxicity from oral biphenyl exposure, reviewed across experimental animal bioassays and mechanistic studies

increases

Not recorded as a finding: a review that discusses its trials without pooling them

The available health effects data for biphenyl provides suggestive evidence for carcinogenicity in humans, based on increased incidences of male rat urinary bladder tumors at high exposure levels and on female mouse liver tumors.

PMID:26529796 · one of two readings recorded this

liver tumor incidence (hepatocellular adenoma/carcinoma), female BDF1 mice

increases

Exposure to biphenyl in the diet for 2 years was associated with a statistically significant dose-related increase in the incidence of liver tumors (hepatocellular adenomas or carcinomas) in female BDF1 mice (Table 3).

PMID:26529796 · one of two readings recorded this

renal toxicity (mineralization, necrosis, hyperplasia)

increases

Kidney toxicity is also a potential human health hazard of biphenyl exposure.

PMID:26529796 · one of two readings recorded this

urinary bladder tumor incidence (transitional cell papilloma/carcinoma), male F344 rats

increases, 31/50 papilloma or carcinoma combined at high dose vs 0/50 controls, n = 50

A dose-related increase in transitional cell papilloma and carcinoma of the urinary bladder was reported in male F344 rats exposed to biphenyl in the diet for 2 years (Table 2).

PMID:26529796 · one of two readings recorded this

breast cancer risk, Group II and Group III PCB congeners

increases, OR = 1.23 (95% CI 1.08-1.40) for Group II; OR = 1.25 (95% CI 1.09-1.43) for Group III

The pooled ORs were 1.23 (95%CI: 1.08–1.40) for group II and 1.25 (95%CI: 1.09–1.43) for group III, respectively.

PMID:26555153 · one of two readings recorded this

breast cancer risk, total PCB exposure (highest vs lowest category)

no effect, OR = 1.09 (95% CI: 0.97-1.22)

Overall, the summary OR of total PCBs was slightly elevated but not statistically significant and heterogeneity was relatively high (OR = 1.09, 95%CI: 0.97–1.22, I2 = 55.4%).

PMID:26555153 · one of two readings recorded this

anti-fungal activity

increases, Some of the compounds have shown significant pharmacological properties.

Some of the compounds have shown significant pharmacological properties.

PMID:28083853 · both readings recorded this

anti-HIV-1 reverse transcriptase inhibition activity

Anti-HIV activity using anti-HIV-1 reverse transcriptase and syncytium inhibition assays, and cytotoxic activity against a panel of cultured mammalian cancer cell lines of isolated compounds were investigated.

PMID:29247893 · one of two readings recorded this

cytotoxic activity against cultured mammalian cancer cell lines

Anti-HIV activity using anti-HIV-1 reverse transcriptase and syncytium inhibition assays, and cytotoxic activity against a panel of cultured mammalian cancer cell lines of isolated compounds were investigated.

PMID:29247893 · one of two readings recorded this

urinary estrone-3-glucuronide, pregnanediol-3-glucuronide and FSH levels across the menstrual cycle

decreases, n = 70

We observed that high (>3.0 parts per billion [ppb]) and medium (>1.0-3.0 ppb) PBB exposure were associated with lower E13G levels across the menstrual cycle and lower FSH levels during the follicular phase, compared with low PBB exposure (≤1.0 ppb).

PMID:31180930 · one of two readings recorded this

urinary reproductive hormone levels (estrone-3-glucuronide, pregnanediol-3-glucuronide, FSH) across the menstrual cycle

decreases, n = 70

Not recorded as a finding: the trial gave a chemically different species

We observed that high (>3.0 parts per billion [ppb]) and medium (>1.0-3.0 ppb) PBB exposure were associated with lower E13G levels across the menstrual cycle and lower FSH levels during the follicular phase, compared with low PBB exposure (≤1.0 ppb).

PMID:31180930 · one of two readings recorded this

Association between polychlorinated biphenyl exposure and breast cancer risk, reviewed across epidemiologic studies

no effect

Not recorded as a finding: the trial gave a chemically different species

However, the results of most epidemiologic studies do not support an association between PCB exposure and breast cancer risk.

PMID:31521536 · one of two readings recorded this

offspring birthweight (lowest quartile) and gestational age by paternal PBB/PCB tertile

increases, aRR = 2.06 (95% CI: 1.12, 3.79), upper paternal PBB tertile vs lower tertile, n = 336

Not recorded as a finding: the trial gave a chemically different species

Lowest quartile offspring birthweight was associated with monotonic increased adjusted risk ratios (aRR) in the middle (aRR=1.67, 95% CI: 0.93, 2.99) and upper tertiles (aRR=2.06, 95% CI = 1.12, 3.79) for PBB (Table 3).

PMID:36041536 · one of two readings recorded this

offspring birthweight, lowest quartile

increases, aRR = 1.67 (95% CI: 0.93, 2.99) middle tertile; aRR = 2.06 (95% CI: 1.12, 3.79) upper tertile, paternal PBB, n = 336

Lowest quartile offspring birthweight was associated with monotonic increased adjusted risk ratios (aRR) in the middle (aRR=1.67, 95% CI: 0.93, 2.99) and upper tertiles (aRR=2.06, 95% CI = 1.12, 3.79) for PBB (Table 3).

PMID:36041536 · one of two readings recorded this

offspring preterm birth / gestational age

no effect

Preterm gestational age was not associated with increasing paternal PBB or PCB levels in the log-risk models (Table 4).

PMID:36041536 · one of two readings recorded this

NLRP3 inflammasome inhibition (binding affinity, IC50) and anti-inflammatory activity in a mouse acute peritonitis model

decreases, IC50 = 0.57 μM; KD = 1.15 μM

Not recorded as a finding: the trial gave a chemically different species

The representative compound H28 was identified as potent and specific NLRP3 inflammasome inhibitor with IC50 values of 0.57 μM.

PMID:38492493 · one of two readings recorded this

NLRP3 inflammasome pathway activation, mouse acute peritonitis model

decreases

The results in a mouse acute peritonitis model revealed that H28 effectively inhibit the NLRP3 inflammasome pathway, demonstrating their anti-inflammatory properties.

PMID:38492493 · one of two readings recorded this

NLRP3 protein binding (KD) and inflammasome assembly/activation inhibition by biphenyl-sulfonamide compound H28, in vitro and in a mouse acute peritonitis model

decreases

Not recorded as a finding: the trial gave a chemically different species

Preliminary mechanistic studies have revealed that compound H28 exhibits direct binding to the NLRP3 protein (KD: 1.15 μM), effectively inhibiting the assembly and activation of the NLRP3 inflammasome.

PMID:38492493 · one of two readings recorded this

diabetes mellitus

increases, OR = 3.593 (95% CI 2.566, 5.031)

The pooled OR showed that PCB congener exposure among the population was highly associated with the risk of DM (OR = 3.593, 95% CI 2.566, 5.031).

PMID:39095444 · one of two readings recorded this

hypertension

no effect, OR = 1.335 (95% CI 0.902, 1.976)

However, the pooled OR showed a lack of association between PCB congener exposure and the risk of HTN (OR = 1.335, 95% CI 0.902, 1.976).

PMID:39095444 · one of two readings recorded this

hypertriglyceridaemia

no effect, OR = 1.611 (95% CI 0.981, 2.643)

The pooled OR was 1.611 (95% CI 0.981, 2.643), suggesting no association between PCB congener exposure and the risk of HTG.

PMID:39095444 · one of two readings recorded this

low HDL cholesterol

decreases, OR = 0.34 (95% CI 0.092, 1.258)

However, the pooled OR (0.34, 95% CI 0.092, 1.258) showed that there was a negative association between PCB congener exposure and the risk of having low HDL.

PMID:39095444 · one of two readings recorded this

metabolic syndrome, dioxin exposure

increases, OR = 2.742 (95% CI 1.936, 3.883)

The pooled OR described minimal association (OR = 2.742, 95% CI 1.936, 3.883).

PMID:39095444 · one of two readings recorded this

metabolic syndrome, PCB exposure

no effect, OR = 1.162 (95% CI 0.994, 1.357)

The pooled OR showed a limited association (OR = 1.162, 95% CI 0.994, 1.357) that was statistically insignificant (P > 0.05).

PMID:39095444 · one of two readings recorded this

obesity (BMI > 30 kg/m2)

no effect, OR = 1.875 (95% CI 0.883, 3.979)

The pooled effects estimated from all three studies showed no statistical significance (P = 0.102, random effect) between the association of PCB congener exposure and an increase in BMI.

PMID:39095444 · one of two readings recorded this

Ectopic lesion growth in a mouse endometriosis model and ERβ-mediated epigenetic regulation following PCB-126 exposure

increases

Not recorded as a finding: the trial gave a chemically different species

In a mouse model of endometriosis, PCB-126 exposure significantly promoted the growth of ectopic lesions by activating the Steroid Receptor Coactivator-1 (SRC-1) isoform/Matrix Metalloproteinase-9 (MMP9)/Estrogen Receptor-β (ERβ) axis, a critical pathway driving disease progression.

PMID:40951281 · one of two readings recorded this

endometriotic ectopic lesion volume and ERβ/AXL/GAS6/DNMT3A pathway activation in mouse and human endometriotic tissue

increases

Not recorded as a finding: the trial gave a chemically different species

Compared to vehicle-treated mice, PCB126 exposure significantly increased the volume of ectopic lesions.

PMID:40951281 · one of two readings recorded this

endometriotic ectopic lesion volume, AXL inhibitor effect

decreases

BMS-777607 treatment significantly reduced the volume of endometriotic lesions in PCB126-exposed mice compared to the vehicle-treated group (and).

PMID:40951281 · one of two readings recorded this

endometriotic ectopic lesion volume

increases

Compared to vehicle-treated mice, PCB126 exposure significantly increased the volume of ectopic lesions.

PMID:40951281 · one of two readings recorded this

Inhibition of LPS-induced nitric oxide release in BV2 microglial cells by six new biphenyl derivatives isolated from Garcinia yunnanensis

decreases

Not recorded as a finding: the trial gave a chemically different species

Additionally, all six new compounds were evaluated for their ability to inhibit LPS-induced nitric oxide (NO) release in BV2 microglial cells, demonstrating moderate anti-inflammatory activity.

PMID:42055094 · one of two readings recorded this

LPS-induced nitric oxide release in BV2 microglial cells

decreases

Additionally, all six new compounds were evaluated for their ability to inhibit LPS-induced nitric oxide (NO) release in BV2 microglial cells, demonstrating moderate anti-inflammatory activity.

PMID:42055094 · one of two readings recorded this

LPS-induced nitric oxide release inhibition in BV2 microglial cells

decreases

Not recorded as a finding: the trial gave a chemically different species

Additionally, all six new compounds were evaluated for their ability to inhibit LPS-induced nitric oxide (NO) release in BV2 microglial cells, demonstrating moderate anti-inflammatory activity.

PMID:42055094 · one of two readings recorded this

blood/tissue PCB congener concentration after known exposure incidents vs general-population controls

increases, 6.9 ppb (Yusho patients) vs 1.6 ppb (Fukuoka controls), n = 11

Figure 1 graphically depicts mean PCB serum levels for the selected tetra through heptachlorinated PCBs in blood of 11 patients as compared to the control blood from the general population.

PMID:8187704 · one of two readings recorded this

blood/tissue PCB congener concentrations in exposed cohorts (Yusho patients, Guam workers, firefighters, exposed children, Vietnam veterans) versus controls

increases, 6.9 ppb (Yusho patients) vs 1.6 ppb (Fukuoka controls), n = 11

Not recorded as a finding: the trial gave a chemically different species

Figure 1 graphically depicts mean PCB serum levels for the selected tetra through heptachlorinated PCBs in blood of 11 patients as compared to the control blood from the general population.

PMID:8187704 · one of two readings recorded this