Compound
SN-38
A semisynthetic camptothecin derivative that inhibits DNA topoisomerase I to prevent nucleic acid synthesis during S phase. It is used as an antineoplastic agent for the treatment of colorectal neoplasms and pancreatic neoplasms.
CHEBI:8988ChEBI
Structure
- Class
- Organic compound
- Formula
- C22H20N2O5
- Mass
- 392.411 g/mol
- Charge
- 0
- InChIKey
- FJHBVJOVLFPMQE-QFIPXVFZSA-N
- SMILES
- CCc1c2c(nc3ccc(O)cc13)-c1cc3c(c(=O)n1C2)COC(=O)[C@]3(O)CC
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
4 statements
4 statements · 1 reference database · Subject: SN-38 · Sources: Rhea
- SN-38 is converted to SN-38 O-beta-D-glucuronideCompoundRhea RHEA:63696Inferred only
- SN-38 is metabolised by UGT1A1ProteinRhea RHEA:63696Inferred only
- SN-38 is metabolised by UGT1A7ProteinRhea RHEA:63696Inferred only
- SN-38 is metabolised by UGT1A9ProteinRhea RHEA:63696Inferred only
Reactions
1 reaction
SN-38+UDP-alpha-D-glucuronateSN-38 O-beta-D-glucuronide+UDP+hydron
Catalysed by UGT1A9 or UGT1A1 or UGT1A7
Reaction pageLeft to rightBalanced
Rhea RHEA:63696CC BY 4.0Reference data
Other names
8 names
Resolves to: SN-38
- Also called
- 10-Hydroxy-7-ethylcamptothecin7-Ethyl-10-hydroxy-20(S)-camptothecin7-Ethyl-10-hydroxycamptothecinNK 012NK-012SN 38SN 38 lactone
- Systematic name
- (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione