.rp{--rp-measure:44rem;--rp-wide:58rem;--rp-px:var(--color-type-protein);color:var(--color-ink-1);background:var(--color-ground);padding:3rem 1rem 5rem}.rp>*{max-width:var(--rp-wide);margin-inline:auto}.rp-head{max-width:var(--rp-measure)}.rp-kicker{font-size:var(--text-xs);color:var(--color-ink-3)}.rp-title{font-family:var(--font-display);letter-spacing:-.015em;color:var(--color-ink);text-wrap:balance;margin-top:.8rem;font-size:clamp(1.6rem,1.1rem + 1.6vw,2.3rem);font-weight:600;line-height:1.15}.rp-byline{font-size:var(--text-sm);color:var(--color-ink-2);margin-top:.8rem}.rp-links{font-size:var(--text-sm);flex-wrap:wrap;gap:.4rem 1.1rem;margin-top:1rem;display:flex}.rp-links a{color:var(--color-ink);text-decoration:underline;-webkit-text-decoration-color:var(--color-accent);text-decoration-color:var(--color-accent);text-underline-offset:3px}.rp-status{border-left:3px solid var(--color-rule-strong);font-size:var(--text-xs);color:var(--color-ink-3);background:var(--color-ground-1);margin-top:1rem;padding:.6rem .8rem}.rp-abstract{max-width:var(--rp-measure);border:1px solid var(--color-rule-faint);background:var(--color-ground-1);border-radius:.6rem;margin-top:2rem;padding:1.2rem 1.4rem}.rp-abstract h2{font-family:var(--font-display);font-size:var(--text-base);color:var(--color-ink);font-weight:650}.rp-abstract p{font-family:var(--font-text);font-size:var(--text-sm);margin-top:.6rem;line-height:1.6}.rp-abstract b{font-family:var(--font-display);color:var(--color-ink)}.rp-body{margin-top:1rem}.rp-body>:not(figure):not(.rp-tablewrap){max-width:var(--rp-measure)}.rp-body h2{font-family:var(--font-display);font-size:var(--text-xl);color:var(--color-ink);margin-top:2.6rem;font-weight:600}.rp-body h3{font-family:var(--font-display);font-size:var(--text-base);color:var(--color-ink);margin-top:1.6rem;font-weight:650}.rp-body p{font-family:var(--font-text);font-size:var(--text-base);text-wrap:pretty;margin-top:.8rem;line-height:1.65}.rp-body p b{font-family:var(--font-display);color:var(--color-ink)}.rp-body a{color:var(--color-ink);text-decoration:underline;-webkit-text-decoration-color:var(--color-accent);text-decoration-color:var(--color-accent);text-underline-offset:3px}.rp code{font-family:var(--font-mono);background:var(--color-ground-2);border-radius:3px;padding:.05em .3em;font-size:.86em}.rp-hash{word-break:break-all}.rp-cite{color:var(--color-ink-3);font-size:.7em;font-family:var(--font-display)}.rp var{font-style:italic;font-family:var(--font-text)}.rp-eq{border-left:3px solid var(--color-accent);background:var(--color-ground-1);margin:1rem 0;padding:.8rem 1.2rem}.rp-eq p{font-size:var(--text-base);margin:.2rem 0!important}.rp-fig{max-width:var(--rp-wide);margin:1.6rem auto}.rp-fig-split{max-width:36rem}.rp-fig figcaption{max-width:var(--rp-measure);font-size:var(--text-xs);color:var(--color-ink-3);margin-top:.5rem;line-height:1.5}.rp-fig figcaption b{color:var(--color-ink);font-family:var(--font-display)}.rp-tablewrap{margin:1.4rem auto;overflow-x:auto}.rp-table{border-collapse:collapse;width:100%;font-size:var(--text-xs);line-height:1.45}.rp-table caption{caption-side:top;text-align:left;color:var(--color-ink-3);padding-bottom:.5rem}.rp-table caption b{color:var(--color-ink);font-family:var(--font-display)}.rp-table th{text-align:left;font-family:var(--font-display);color:var(--color-ink);border-bottom:1.5px solid var(--color-rule-strong);white-space:nowrap;padding:.35rem .6rem .35rem 0;font-weight:650}.rp-table td{border-bottom:1px solid var(--color-rule-faint);vertical-align:top;padding:.35rem .6rem .35rem 0}.rp-table q{font-family:var(--font-text);color:var(--color-ink-2)}.rp-num,.rp-table-num td:not(:first-child){font-family:var(--font-mono);font-variant-numeric:tabular-nums;white-space:nowrap}.rp-table-num td:not(:first-child),.rp-table-num th:not(:first-child){text-align:right}.rp-total td{color:var(--color-ink);border-top:1px solid var(--color-rule);font-weight:600}.rp-table-obs tr[data-miss] td{background:color-mix(in oklch, var(--color-accent) 7%, transparent)}.rp-q{min-width:16rem}.rp-tag{border:1px solid var(--color-rule);font-family:var(--font-display);color:var(--color-ink-3);white-space:nowrap;border-radius:3px;margin-left:.35rem;padding:0 .3rem;font-size:.72rem;display:inline-block}.rp-refs{font-size:var(--text-xs);margin-top:.8rem;padding-left:1.6rem;line-height:1.55}.rp-refs li{margin-top:.35rem}.rp-role{color:var(--color-ink-3)}.rf{width:100%;height:auto;font-family:var(--font-display);display:block}.rf-square{max-width:32rem;margin:0 auto}.rf-box rect{fill:var(--color-ground-1);stroke:var(--color-ink-2);stroke-width:1.2px}.rf-dotted rect{fill:none;stroke-dasharray:2 4}.rf-target rect{stroke:var(--rp-px);fill:color-mix(in oklch, var(--rp-px) 8%, var(--color-ground-1))}.rf-title{fill:var(--color-ink);font-size:13px;font-weight:650}.rf-sub{fill:var(--color-ink-3);font-size:10.5px;font-family:var(--font-mono)}.rf-arrow{fill:none;stroke:var(--color-accent);stroke-width:1.5px}.rf-arrow-dotted{stroke:var(--rp-px);stroke-dasharray:3 3}.rf-headfill{fill:var(--color-accent)}.rf-rate{fill:var(--color-ink-2);font-size:10.5px;font-family:var(--font-mono);paint-order:stroke;stroke:var(--color-ground);stroke-width:4px}.rf-note{fill:var(--color-ink-3);font-size:10.5px;font-family:var(--font-mono)}.rf-grid{stroke:var(--color-rule-faint);stroke-width:1px}.rf-axis{fill:var(--color-ink-3);font-variant-numeric:tabular-nums;font-size:10.5px}.rf-axis-strong{fill:var(--color-ink-2);font-size:11px}.rf-axis-occ{fill:var(--rp-px)}.rf-night{fill:color-mix(in oklch, var(--rp-px) 7%, transparent)}.rf-cp{fill:none;stroke:var(--color-accent);stroke-width:2.4px}.rf-px{fill:none;stroke:var(--rp-px);stroke-width:2px}.rf-tb{fill:none;stroke:var(--color-ink-2);stroke-width:1.5px;stroke-dasharray:6 3}.rf-tp{fill:none;stroke:var(--color-ink-3);stroke-width:1.5px;stroke-dasharray:2 3}.rf-occ{fill:none;stroke:var(--rp-px);stroke-width:1.4px;stroke-dasharray:1 3;stroke-linecap:round}.rf-legend line{stroke-width:2.4px}.rf-zone{fill:color-mix(in oklch, var(--color-accent) 7%, transparent)}.rf-identity{stroke:var(--color-ink-2);stroke-width:1.2px}.rf-twofold{stroke:var(--color-ink-3);stroke-width:1px;stroke-dasharray:4 4}.rf-afe{stroke:var(--color-ink);stroke-width:2px}.rf-pt{stroke:var(--color-ground);stroke-width:1px}.rf-pt[data-src=library]{stroke-width:1.8px;fill:var(--color-ground)!important}.rf-m-0{fill:var(--color-accent);stroke:var(--color-accent)}.rf-m-1{fill:var(--color-type-cell-type);stroke:var(--color-type-cell-type)}.rf-m-2{fill:var(--color-type-outcome);stroke:var(--color-type-outcome)}.rf-m-3{fill:var(--color-type-process);stroke:var(--color-type-process)}.rf-m-4{fill:var(--rp-px);stroke:var(--rp-px)}.rf-m-5{fill:var(--color-type-pathway);stroke:var(--color-type-pathway)}.rf-m-6{fill:var(--color-ink-3);stroke:var(--color-ink-3)}.rf-pt[data-src=record]{stroke:var(--color-ground)}.rf-pt-px{stroke-width:2.4px!important}.rf-pos{fill:var(--color-direction-increases)}.rf-neg{fill:var(--color-direction-decreases)}.rf-cell{font-size:11px;font-family:var(--font-mono);fill:var(--color-ink);font-variant-numeric:tabular-nums}@media (max-width:640px){.rp{padding-top:2rem}.rp-abstract{padding:1rem}}.rf-key{font-family:var(--font-display);font-size:var(--text-2xs);color:var(--color-ink-3);flex-wrap:wrap;justify-content:center;gap:.3rem 1rem;margin-top:.4rem;display:flex}.rf-key span{align-items:center;gap:.35rem;display:inline-flex}